Books for the General Public

The Okinawa Program, a New York Times Bestseller and authored by a team of internationally renowned experts, is based on the landmark scientifically documented twenty-five-year Okinawa Centenarian Study, a Japanese Ministry of Health-sponsored study. This breakthrough book reveals the diet, exercise, and lifestyle practices that make the Okinawans the healthiest and longest-lived population in the world. With an easy-to-follow Four-Week Turnaround Plan, nearly one hundred fast, delicious recipes, and a moderate exercise plan, The Okinawa Program can dramatically increase your chances for a long, healthy life.

In The Okinawa Diet Plan, Drs. Bradley and Craig Willcox and Makoto Suzuki offer a practical diet program rooted in Okinawan traditions so that you too can have a leaner, more “metabolically efficient” body that will stay healthier and more youthful. Conveniently divided into three dietary tracks—western, eastern, and a fusion plan that combines both—their program will help you achieve healthy weight loss without deprivation. With more than 150 recipes, an eight-week phase-in plan, and other unique resources, The Okinawa Diet Plan is an easy-to-follow breakthrough concept in healthy weight loss.

Books for the General Public

The Okinawa Program, a New York Times Bestseller and authored by a team of internationally renowned experts, is based on the landmark scientifically documented twenty-five-year Okinawa Centenarian Study, a Japanese Ministry of Health-sponsored study. This breakthrough book reveals the diet, exercise, and lifestyle practices that make the Okinawans the healthiest and longest-lived population in the world. With an easy-to-follow Four-Week Turnaround Plan, nearly one hundred fast, delicious recipes, and a moderate exercise plan, The Okinawa Program can dramatically increase your chances for a long, healthy life.

In The Okinawa Diet Plan, Drs. Bradley and Craig Willcox and Makoto Suzuki offer a practical diet program rooted in Okinawan traditions so that you too can have a leaner, more “metabolically efficient” body that will stay healthier and more youthful. Conveniently divided into three dietary tracks—western, eastern, and a fusion plan that combines both—their program will help you achieve healthy weight loss without deprivation. With more than 150 recipes, an eight-week phase-in plan, and other unique resources, The Okinawa Diet Plan is an easy-to-follow breakthrough concept in healthy weight loss.

Selected Publications by OCS Researchers

The OCS and its researchers have published hundreds of peer-reviewed scientific publications which include scientific manuscripts, conference proceedings, books, and book chapters on aging and health. Below are selected publications of major findings of the OCS and its researchers.

2020-CURRENT

Frankum, R., Jameson, T., Knight, B. A., Stephens, F. B., Wall, B. T., Donlon, T. A., Torigoe, T., Willcox, B. J., Willcox, D. C., Allsopp, R. C., & Harries, L. W. (2021). Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels. GeroScience, 10.1007/s11357-021-00431-0. Pubmed PMID: 34436732.

Klinpudtan, N., Allsopp, R. C., Kabayama, M., Godai, K., Gondo, Y., Masui, Y., Akagi, Y., Srithumsuk, W., Sugimoto, K., Akasaka, H., Takami, Y., Takeya, Y., Yamamoto, K., Ikebe, K., Yasumoto, S., Ogawa, M., Ishizaki, T., Arai, Y., Rakugi, H., Chen, R., … Kamide, K. (2021). The association between longevity associated FOXO3 allele and heart disease in Septuagenarians and Octogenarians: The SONIC study. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, glab204. Pubmed PMID: 34254639.

Donlon, T. A., Chen, R., Masaki, K. H., Willcox, D. C., Allsopp, R. C., Willcox, B. J., & Morris, B. J. (2021). Association of growth hormone receptor gene variant with longevity in men is due to amelioration of increased mortality risk from hypertension. Aging, 13(11), 14745–14767. Pubmed PMID: 34074802.

Sorrenti, V., Castagna, D. A., Fortinguerra, S., Buriani, A., Scapagnini, G., & Willcox, D. C. (2021). Spirulina Microalgae and Brain Health: A Scoping Review of Experimental and Clinical Evidence. Marine Drugs, 19(6), 293. Pubmed PMID: 34067317.

Watanabe, K., Higa, M., Hasegawa, Y., Kudo, A., Allsopp, R. C., Willcox, B. J., Willcox, D. C., Sata, M., Masuzaki, H., & Shimabukuro, M. (2021). Regional Variations of Insulin Secretion and Insulin Sensitivity in Japanese Participants With Normal Glucose Tolerance. Frontiers in Nutrition, 8, 632422. Pubmed PMID: 33829033.

Morris, B. J., Chen, R., Donlon, T. A., Masaki, K. H., Willcox, D. C., Allsopp, R. C., & Willcox, B. J. (2021). Lifespan extension conferred by mitogen-activated protein kinase kinase kinase 5 (MAP3K5) longevity-associated gene variation is confined to at-risk men with a cardiometabolic disease. Aging, 13(6), 7953–7974. Pubmed PMID: 33739303.

Chen, R., Morris, B. J., Donlon, T. A., Masaki, K. H., Willcox, D. C., Davy, P., Allsopp, R. C., & Willcox, B. J. (2020). FOXO3 longevity genotype mitigates the increased mortality risk in men with a cardiometabolic disease. Aging, 12(23), 23509–23524. Pubmed PMID: 33260156.

Sorrenti, V., Davinelli, S., Scapagnini, G., Willcox, B. J., Allsopp, R. C., & Willcox, D. C. (2020). Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging. Marine Drugs, 18(7), 351. Pubmed PMID: 32635607.

2015-2019

Donlon, T. A., Davy, P. M. C., & Willcox, B. J. (2019). Analysis of FOXO3 gene polymorphisms associated with human longevity. Methods in Molecular Biology (Clifton, N.J.), 1890, 251. Pubmed PMID: 30414160.

Davy, P. M. C., Willcox, D. C., Shimabukuro, M., Donlon, T. A., Torigoe, T., Suzuki, M., . . . Willcox, B. J. (2018). Minimal shortening of leukocyte telomere length across age groups in a cross-sectional study for carriers of a longevity-associated FOXO3 allele. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 73(11), 1448-1452. Pubmed PMID: 29688278.

Donlon, T. A., Morris, B. J., Chen, R., Masaki, K. H., Allsopp, R. C., Willcox, D. C., . . . Willcox, B. J. (2018). Analysis of polymorphisms in 59 potential candidate genes for association with human longevity. The Journals of Gerontology: Series A, 73(11), 1459-1464. Pubmed PMID: 29300832.

Kadowaki, S., Miura, K., Kadowaki, T., Fujiyoshi, A., El-Saed, A., Masaki, K. H., . . . ERA JUMP Study Group. (2018). International comparison of abdominal fat distribution among four populations: The ERA-JUMP study. Metabolic Syndrome and Related Disorders, 16(4), 166-173. Pubmed PMID: 29715072.

Davy, P. M. C., Allsopp, R. C., Donlon, T. A., Morris, B. J., Willcox, D. C., & Willcox, B. J. (2018). FOXO3 and exceptional longevity: Insights from hydra to humans. Current Topics in Developmental Biology, 127, 193-212. Pubmed PMID: 29433738.

Wahab, N., Chen, R., Curb, J. D., Willcox, B. J., & Rodriguez, B. L. (2018). The association of fasting glucose, insulin, and C-peptide, with 19-year incidence of coronary heart disease in older Japanese-American men; the Honolulu Heart Program. Geriatrics (Basel, Switzerland), 3(2). Pubmed PMID: 30555835.

Donlon, T. A., Willcox, B. J., & Morris, B. J. (2017). FOXO3 cell resilience gene neighborhood. Aging, 9(12), 2467-2468. Pubmed PMID: 29242406.

Donlon, T. A., Morris, B. J., Chen, R., Masaki, K. H., Allsopp, R. C., Willcox, D. C., . . . Willcox, B. J. (2017). FOXO3 longevity interactome on chromosome 6. Aging Cell, 16(5), 1016-1025. Pubmed PMID: 28722347.

Donlon, T. A., Morris, B. J., He, Q., Chen, R., Masaki, K. H., Allsopp, R. C., . . . Willcox, B. J. (2017). Association of polymorphisms in connective tissue growth factor and epidermal growth factor receptor genes with human longevity. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 72(8), 1038-1044. Pubmed PMID: 27365368.

Willcox, B. J., Willcox, D. C., & Suzuki, M. (2017). Demographic, phenotypic, and genetic characteristics of centenarians in Okinawa and Japan: Part 1-centenarians in Okinawa. Mechanisms of Ageing and Development, 165(Pt B), 75-79. Pubmed PMID: 27845177.

Shao, A., Drewnowski, A., Willcox, D. C., Kramer, L., Lausted, C., Eggersdorfer, M., . . . Griffiths, J. C. (2017). Optimal nutrition and the ever-changing dietary landscape: A conference report. European Journal of Nutrition, 56(Suppl 1), 1-21. Pubmed PMID: 28474121.

Willcox, B. J., Morris, B. J., Tranah, G. J., Chen, R., Masaki, K. H., He, Q., . . . Donlon, T. A. (2017). Longevity-associated FOXO3 genotype and its impact on coronary artery disease mortality in Japanese, Whites, and Blacks: A prospective study of three American populations. The Journals of Gerontology.Series A, Biological Sciences and Medical Sciences, 72(5), 724-728. Pubmed PMID: 27694344.

Guo, J., Fujiyoshi, A., Masaki, K., Vishnu, A., Kadota, A., Barinas-Mitchell, E. J., . . . Sekikawa, A. (2017). The role of initial and longitudinal change in blood pressure on progression of arterial stiffness among multiethnic middle-aged men. Journal of Hypertension, 35(1), 111-117. Pubmed PMID: 27775956.

Morris, B. J., Chen, R., Donlon, T. A., Evans, D. S., Tranah, G. J., Parimi, N., . . . Willcox, B. J. (2016). Association analysis of FOXO3 longevity variants with blood pressure and essential hypertension. American Journal of Hypertension, 29(11), 1292-1300. Pubmed PMID: 26476085.

Willcox, B. J., Tranah, G. J., Chen, R., Morris, B. J., Masaki, K. H., He, Q., . . . Donlon, T. A. (2016). The FoxO3 gene and cause-specific mortality. Aging Cell, 15(4), 617-624. Pubmed PMID: 27071935.

Le Couteur, D. G., Solon-Biet, S., Wahl, D., Cogger, V. C., Willcox, B. J., Willcox, D. C., . . . Simpson, S. J. (2016). New horizons: Dietary protein, ageing and the Okinawan ratio. Age and Ageing, 45(4), 443-447. Pubmed PMID: 27130207.

Zeng, Y., Chen, H., Ni, T., Ruan, R., Nie, C., Liu, X., . . . Vaupel, J. W. (2016). Interaction between the FOXO1A-209 genotype and tea drinking is significantly associated with reduced mortality at advanced ages. Rejuvenation Research, 19(3), 195-203. Pubmed PMID: 26414954.

Davinelli, S., Maes, M., Corbi, G., Zarrelli, A., Willcox, D. C., & Scapagnini, G. (2016). Dietary phytochemicals and neuro-inflammaging: From mechanistic insights to translational challenges. Immunity & Ageing : I & A, 13, 3. eCollection 2016. Pubmed PMID: 27081392.

Nishihira, J., Tokashiki, T., Higashiuesato, Y., Willcox, D. C., Mattek, N., Shinto, L., . . . Dodge, H. H. (2016). Associations between serum omega-3 fatty acid levels and cognitive functions among community-dwelling octogenarians in Okinawa, Japan: The KOCOA study.Journal of Alzheimer’s Disease : JAD, 51(3), 857-866. Pubmed PMID: 26890763.

Suzuki, M., Willcox, D. C., & Willcox, B. (2016). Okinawa centenarian study: Investigating healthy aging among the world’s longest-lived people. Encyclopedia of geropsychology (pp. 1-5) doi:10.1007/978-981-287-080-3_74-1 Retrieved from https://app.dimensions.ai/details/publication/pub.1017860454

El-Saed, A., Masaki, K., Okamura, T., Evans, R. W., Nakamura, Y., Willcox, B. J., . . . ERAJump Study Group. (2016). The associations of C-reactive protein with serum levels of polyunsaturated fatty acids and trans fatty acids among middle-aged men from three populations. The Journal of Nutrition, Health & Aging, 20(1), 16-21. Pubmed PMID: 26728928.

Sekikawa, A., Miyamoto, Y., Miura, K., Nishimura, K., Willcox, B. J., Masaki, K. H., . . . Kuller, L. H. (2015). Continuous decline in mortality from coronary heart disease in japan despite a continuous and marked rise in total cholesterol: Japanese experience after the seven countries study. International Journal of Epidemiology, 44(5), 1614-1624. Pubmed PMID: 26182938.

Morris, B. J., Carnes, B. A., Chen, R., Donlon, T. A., He, Q., Grove, J. S., . . . Willcox, B. J. (2015). Genetic variation in the raptor gene is associated with overweight but not hypertension in american men of japanese ancestry. American Journal of Hypertension, 28(4), 508-517. Pubmed PMID: 25249372.

Zeng, Y., Chen, H., Ni, T., Ruan, R., Feng, L., Nie, C., . . . Vaupel, J. W. (2015). GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in china. The Journals of Gerontology.Series A, Biological Sciences and Medical Sciences, 70(4), 426-433. Pubmed PMID: 24895270.

El Khoudary, S. R., Shin, C., Masaki, K., Miura, K., Budoff, M., Edmundowicz, D., . . . ERA JUMP Study Group. (2015). Ectopic cardiovascular fat in middle-aged men: Effects of race/ethnicity, overall and central adiposity. the ERA JUMP study. International Journal of Obesity (2005), 39(3), 488-494. Pubmed PMID: 25109783.

Karino, S., Willcox, B. J., Fong, K., Lo, S., Abbott, R., & Masaki, K. H. (2015). Total and differential white blood cell counts predict eight-year incident coronary heart disease in elderly Japanese-American men: The Honolulu Heart Program. Atherosclerosis, 238(2), 153-158. Pubmed PMID: 25514532.

Martin, P., Kelly, N., Kahana, B., Kahana, E., Willcox, B. J., Willcox, D. C., & Poon, L. W. (2015). Defining successful aging: A tangible or elusive concept? The Gerontologist, 55(1), 14-25. Pubmed PMID: 24840916.

Morris, B. J., Donlon, T. A., He, Q., Grove, J. S., Masaki, K. H., Elliott, A., . . . Willcox, B. J. (2015). Genetic analysis of TOR complex gene variation with human longevity: A nested case-control study of american men of japanese ancestry. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 70(2), 133-142. Pubmed PMID: 24589862.

Morris, B. J., Willcox, D. C., Donlon, T. A., & Willcox, B. J. (2015). FOXO3: A major gene for human longevity–A mini-review. Gerontology, 61(6), 515-525. Pubmed PMID: 25832544.

Nagasawa, S. Y., Ohkubo, T., Masaki, K., Barinas-Mitchell, E., Miura, K., Seto, T., . . . ERA-JUNP Study Group. (2015). Associations between inflammatory markers and subclinical atherosclerosis in middle-aged White, Japanese-American and Japanese men: The ERA-JUMP study. Journal of Atherosclerosis and Thrombosis, 22(6), 590-598. Pubmed PMID: 25445888.

2010-2014

Bendjilali, N., Hsueh, W. C., He, Q., Willcox, D. C., Nievergelt, C. M., Donlon, T. A., . . . Willcox, B. J. (2014). Who are the Okinawans? ancestry, genome diversity, and implications for the genetic study of human longevity from a geographically isolated population. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 69(12), 1474-1484. Pubmed PMID: 24444611.

Carnes, B. A., Staats, D., & Willcox, B. J. (2014). Impact of climate change on elder health. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 69(9), 1087-1091. Pubmed PMID: 24158763.

He, Q., Morris, B. J., Grove, J. S., Petrovitch, H., Ross, W., Masaki, K. H., . . . Willcox, B. J. (2014). Shorter men live longer: Association of height with longevity and FOXO3 genotype in american men of japanese ancestry. PloS One, 9(5), e94385. Pubmed PMID: 24804734.

Bell, C. L., Chen, R., Masaki, K., Yee, P., He, Q., Grove, J., . . . Willcox, B. J. (2014). Late-life factors associated with healthy aging in older men. Journal of the American Geriatrics Society, 62(5), 880-888. Pubmed PMID: 24779449.

Sekikawa, A., Miura, K., Lee, S., Fujiyoshi, A., Edmundowicz, D., Kadowaki, T., . . . ERA JUMP Study Group. (2014). Long chain n-3 polyunsaturated fatty acids and incidence rate of coronary artery calcification in Japanese men in Japan and White men in the USA: Population based prospective cohort study. Heart (British Cardiac Society), 100(7), 569-573. Pubmed PMID: 24352736.

Park, Y., Wang, S., Kitahara, C. M., Moore, S. C., Berrington de Gonzalez, A., Bernstein, L., . . . Willett, W. C. (2014). Body mass index and risk of death in Asian Americans. American Journal of Public Health, 104(3), 520-525. Pubmed PMID: 24432919.

Morris, B. J., Donlon, T. A., He, Q., Grove, J. S., Masaki, K. H., Elliott, A., . . . Willcox, B. J. (2014). Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 69(3), 270-273. Pubmed PMID: 23770741.

Willcox, D. C., Scapagnini, G., & Willcox, B. J. (2014). Healthy aging diets other than the Mediterranean: A focus on the Okinawan diet. Mechanisms of Ageing and Development, 136-137, 148-162. Pubmed PMID: 24462788.

Vishnu, A., Choo, J., Masaki, K. H., Mackey, R. H., Barinas-Mitchell, E., Shin, C., . . . ERA JUMP Study Group. (2014). Particle numbers of lipoprotein subclasses and arterial stiffness among middle-aged men from the ERA JUMP study. Journal of Human Hypertension, 28(2), 111-117. Pubmed PMID: 23823580.

Choo, J., Shin, C., Barinas-Mitchell, E., Masaki, K., Willcox, B. J., Seto, T. B., . . . Sekikawa, A. (2014). Regional pulse wave velocities and their cardiovascular risk factors among healthy middle-aged men: A cross-sectional population-based study. BMC Cardiovascular Disorders, 14, 5. Pubmed PMID: 24410766.

Willcox, B. J., & Willcox, D. C. (2014). Caloric restriction, caloric restriction mimetics, and healthy aging in okinawa: Controversies and clinical implications. Current Opinion in Clinical Nutrition and Metabolic Care, 17(1), 51-58. Pubmed PMID: 24316687.

Sekikawa, A., Shin, C., Masaki, K. H., Barinas-Mitchell, E. J., Hirooka, N., Willcox, B. J., . . . ERA JUMP Study Group. (2013). Association of total marine fatty acids, eicosapentaenoic and docosahexaenoic acids, with aortic stiffness in Koreans, Whites, and Japanese Americans. American Journal of Hypertension, 26(11), 1321-1327. Pubmed PMID: 23820020.

Sekikawa, A., Willcox, B. J., Usui, T., Carr, J. J., Barinas-Mitchell, E. J., Masaki, K. H., . . . Miyamoto, Y. (2013). Do differences in risk factors explain the lower rates of coronary heart disease in japanese versus U.S. women? Journal of Women’s Health (Larchmt) 22(11), 966-977. Pubmed PMID: 24073782.

Fujiyoshi, A., Sekikawa, A., Shin, C., Masaki, K., David Curb, J., Ohkubo, T., . . . ERA JUMP (Electron-Beam Tomography, Risk Factor Assessment Among Japanese and U. S. Men in the Post-World War II Birth Cohort) Study Group. (2013). A cross-sectional association of obesity with coronary calcium among japanese, koreans, japanese americans, and U.S. whites. European Heart Journal Cardiovascular Imaging, 14(9), 921-927. Pubmed PMID: 23764486.

Hirooka, N., Shin, C., Masaki, K. H., Edmundowicz, D., Choo, J., Barinas-Mitchell, E. J., . . . Sekikawa, A. (2013). The associations of indices of obesity with lipoprotein subfractions in Japanese American, African American and Korean men. Global Heart, 8(3), 273-280. Pubmed PMID: 25068101.

Robine, J. M., Herrmann, F. R., Arai, Y., Willcox, D. C., Gondo, Y., Hirose, N., . . . Saito, Y. (2013). Accuracy of the centenarian numbers in okinawa and the role of the okinawan diet on longevity: Responses to le bourg about the article “exploring the impact of climate on human longevity”. Experimental Gerontology, 48(8), 840-842. Pubmed PMID: 23711883.

Willcox, B., Suzuki, M., Donlon, T., He, Q., Grove, J., Masaki, K., & Willcox, D. (2013). Optimizing Human Health Span and Life Span: Insights From Okinawa and Hawaii. Annual Review of Gerontology & Geriatrics, 33, 135–XIV. Retrieved from http://search.proquest.com/docview/1462417090/

Katsumata, Y., Todoriki, H., Higashiuesato, Y., Yasura, S., Ohya, Y., Willcox, D. C., & Dodge, H. H. (2013). Very old adults with better memory function have higher low-density lipoprotein cholesterol levels and lower triglyceride to high-density lipoprotein cholesterol ratios: KOCOA project. Journal of Alzheimer’s Disease : JAD, 34(1), 273-279. Pubmed PMID: 23207484.

Mori, N., Armada, F., & Willcox, D. C. (2012). Walking to school in japan and childhood obesity prevention: New lessons from an old policy. American Journal of Public Health, 102(11), 2068-2073. Pubmed PMID: 22994195.

Donlon, T. A., Curb, J. D., He, Q., Grove, J. S., Masaki, K. H., Rodriguez, B., . . . Willcox, B. J. (2012). FOXO3 gene variants and human aging: Coding variants may not be key players. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 67(11), 1132-1139. Pubmed PMID: 22459618.

Robine, J. M., Herrmann, F. R., Arai, Y., Willcox, D. C., Gondo, Y., Hirose, N., . . . Saito, Y. (2012). Exploring the impact of climate on human longevity. Experimental Gerontology, 47(9), 660-671. Pubmed PMID: 22613089.

Sekikawa, A., Steingrimsdottir, L., Ueshima, H., Shin, C., Curb, J. D., Evans, R. W., . . . Gudnason, V. (2012). Serum levels of marine-derived n-3 fatty acids in icelanders, japanese, koreans, and americans–a descriptive epidemiologic study. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 87(1), 11-16. Pubmed PMID: 22658580.

Rantanen, T., Masaki, K., He, Q., Ross, G. W., Willcox, B. J., & White, L. (2012). Midlife muscle strength and human longevity up to age 100 years: A 44-year prospective study among a decedent cohort. Age (Dordrecht, Netherlands), 34(3), 563-570. Pubmed PMID: 21541735.

Davinelli, S., Willcox, D. C., & Scapagnini, G. (2012). Extending healthy ageing: Nutrient sensitive pathway and centenarian population.Immunity & Ageing : I & A, 9, 9. Pubmed PMID: 22524452.

Hassen, L. J., Ueshima, H., Curb, J. D., Choo, J., Lee, S., Masaki, K., . . . Sekikawa, A. (2012). Significant inverse association of marine n-3 fatty acids with plasma fibrinogen levels in Japanese in Japan but not in Whites or Japanese Americans. European Journal of Clinical Nutrition, 66(3), 329-335. Pubmed PMID: 22524452.

Willcox, D. C., Willcox, B. J., Yasura, S., Ashitomi, I., & Suzuki, M. (2012). Gender gap in healthspan and life expectancy in Okinawa: health behaviours. Asian Journal of Gerontology & Geriatrics, 7, 49-58. PDF

Katsumata, Y., Todoriki, H., Higashiuesato, Y., Yasura, S., Willcox, D. C., Ohya, Y., . . . Dodge, H. H. (2012). Metabolic syndrome and cognitive decline among the oldest old in okinawa: In search of a mechanism. the KOCOA project. The Journals of Gerontology.Series A, Biological Sciences and Medical Sciences, 67(2), 126-134. Pubmed PMID: 22016359

Genkinger, J. M., Spiegelman, D., Anderson, K. E., Bernstein, L., van den Brandt, P. A., Calle, E. E., . . . Smith-Warner, S. A. (2011). A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk. International Journal of Cancer, 129(7), 1708-1717. Pubmed PMID: 21105029.

Shikany, J. M., Flood, A. P., Kitahara, C. M., Hsing, A. W., Meyer, T. E., Willcox, B. J., . . . Ziegler, R. G. (2011). Dietary carbohydrate, glycemic index, glycemic load, and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO) cohort. Cancer Causes & Control : CCC, 22(7), 995-1002. Pubmed PMID: 21553078.

Balard, F., Beluche, I., Romieu, I., Willcox, D. C., & Robine, J. M. (2011). Are men aging as oaks and women as reeds? A behavioral hypothesis to explain the gender paradox of French centenarians. Journal of Aging Research, 2011, 371039. Pubmed PMID: 22175018.

Berrington de Gonzalez, A., Hartge, P., Cerhan, J. R., Flint, A. J., Hannan, L., MacInnis, R. J., . . . Thun, M. J. (2010). Body-mass index and mortality among 1.46 million white adults. The New England Journal of Medicine, 363(23), 2211-2219. Pubmed PMID: 21121834.

Dodge, H. H., Katsumata, Y., Todoriki, H., Yasura, S., Willcox, D. C., Bowman, G. L., . . . Traber, M. G. (2010). Comparisons of plasma/serum micronutrients between Okinawan and Oregonian elders: A pilot study. The Journals of Gerontology.Series A, Biological Sciences and Medical Sciences, 65(10), 1060-1067. Pubmed PMID: 20643702.

Willcox, D. C., Willcox, B. J., & Poon, L. W. (2010). Centenarian studies: Important contributors to our understanding of the aging process and longevity. Current Gerontology and Geriatrics Research, 2010, 484529. Pubmed PMID: 21804821.

Suzuki, M., Willcox, D. C., Rosenbaum, M. W., & Willcox, B. J. (2010). Oxidative stress and longevity in okinawa: An investigation of blood lipid peroxidation and tocopherol in okinawan centenarians. Current Gerontology and Geriatrics Research, 2010, 380460. Pubmed PMID: 21490698.

Ceria-Ulep, C. D., Grove, J., Chen, R., Masaki, K. H., Rodriguez, B. L., Donlon, T. A., . . . Curb, J. D. (2010). Physical aspects of healthy aging: Assessments of three measures of balance for studies in middle-aged and older adults. Current Gerontology and Geriatrics Research, 2010, 849761. Pubmed PMID: 21437003.

Rosenbaum, M. W., Willcox, B. J., Willcox, D. C., & Suzuki, M. (2010). Okinawa: A naturally calorie restricted population. Calorie restriction, aging and longevity (pp. 43-53) Springer.

2005-2009

He, Q., & Willcox, B. J. (2009). Linkage disequilibrium of single-nucleotide polymorphism data: How sampling methods affect estimates of linkage disequilibrium. BMC Proceedings, 3 Suppl 7, S105. Pubmed PMID: 20017969.

Sue, L. Y., Schairer, C., Ma, X., Williams, C., Chang, S. C., Miller, A. B., . . . Ziegler, R. G. (2009). Energy intake and risk of postmenopausal breast cancer: An expanded analysis in the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO) cohort. Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 18(11), 2842-2850. Pubmed PMID: 19843674.

Willcox, D. C., Willcox, B. J., Todoriki, H., & Suzuki, M. (2009). The Okinawan diet: Health implications of a low-calorie, nutrient-dense, antioxidant-rich dietary pattern low in glycemic load. Journal of the American College of Nutrition, 28 Suppl, 516S. Pubmed PMID: 20234038.

Willcox, D. 2009. “Aging, Reciprocal Dependency and Changing Social Support Systems in a Rural Okinawan Village.” Okinawa International University Journal of Social Welfare and Psychology, 7(1), 13-56.

Motoyama, K. R., Curb, J. D., Kadowaki, T., El-Saed, A., Abbott, R. D., Okamura, T., . . . Sekikawa, A. (2009). Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men. The American Journal of Clinical Nutrition, 90(1), 49-55. Pubmed PMID: 19474136.

Koropatnick, T. A., Kimbell, J., Chen, R., Grove, J. S., Donlon, T. A., Masaki, K. H., . . . Curb, J. D. (2008). A prospective study of high-density lipoprotein cholesterol, cholesteryl ester transfer protein gene variants, and healthy aging in very old Japanese-American men.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 63(11), 1235-1240. Pubmed PMID: 19038839.

Willcox, D. C., Willcox, B. J., Wang, N. C., He, Q., Rosenbaum, M., & Suzuki, M. (2008). Life at the extreme limit: Phenotypic characteristics of supercentenarians in Okinawa. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 63(11), 1201-1208. Pubmed PMID: 19038835.

Willcox, B. J., Willcox, D. C., & Ferrucci, L. (2008). Secrets of healthy aging and longevity from exceptional survivors around the globe: Lessons from octogenarians to supercentenarians. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 63(11), 1181-1185. Pubmed PMID: 19038832.

Willcox, B. J., Donlon, T. A., He, Q., Chen, R., Grove, J. S., Yano, K., . . . Curb, J. D. (2008). FOXO3A genotype is strongly associated with human longevity. Proceedings of the National Academy of Sciences of the United States of America, 105(37), 13987-13992. Pubmed PMID: 18765803.

Sekikawa, A., Curb, J. D., Ueshima, H., El-Saed, A., Kadowaki, T., Abbott, R. D., . . . ERA JUMP (Electron-Beam Tomography, Risk Factor Assessment Among Japanese and U. S. Men in the Post-World War II Birth Cohort) Study Group. (2008). Marine-derived n-3 fatty acids and atherosclerosis in japanese, japanese-american, and white men: A cross-sectional study. Journal of the American College of Cardiology, 52(6), 417-424. Pubmed PMID: 18672160.

Willcox, B. J., Curb, J. D., & Rodriguez, B. L. (2008). Antioxidants in cardiovascular health and disease: Key lessons from epidemiologic studies. The American Journal of Cardiology, 101(10A), 86D. Pubmed PMID: 18474278.

Willcox, D. C., Willcox, B. J., He, Q., Wang, N. C., & Suzuki, M. (2008). They really are that old: A validation study of centenarian prevalence in Okinawa. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 63(4), 338-349. Pubmed PMID: 18426957.

Abbott, R. D., Ueshima, H., Masaki, K. H., Willcox, B. J., Rodriguez, B. L., Ikeda, A., . . . Curb, J. D. (2007). Coronary artery calcification and total mortality in elderly men. Journal of the American Geriatrics Society, 55(12), 1948-1954. Pubmed PMID: 18426957.

Abbott, R. D., Ueshima, H., Rodriguez, B. L., Kadowaki, T., Masaki, K. H., Willcox, B. J., . . . Curb, J. D. (2007). Coronary artery calcification in Japanese men in Japan and Hawaii. American Journal of Epidemiology, 166(11), 1280-1287. Pubmed PMID: 17971135.

Willcox, B. J., Willcox, D. C., Todoriki, H., Fujiyoshi, A., Yano, K., He, Q., . . . Suzuki, M. (2007). Caloric restriction, the traditional Okinawan diet, and healthy aging: The diet of the world’s longest-lived people and its potential impact on morbidity and life span. Annals of the New York Academy of Sciences, 1114, 434-455. Pubmed PMID: 17986602.

Willcox, D. C., Willcox, B. J., Sokolovsky, J., & Sakihara, S. (2007). The cultural context of “successful aging” among older women weavers in a northern Okinawan village: The role of productive activity. Journal of Cross-Cultural Gerontology, 22(2), 137-165. Pubmed PMID: 17318443.

Willcox, D. C., Willcox, B. J., Shimajiri, S., Kurechi, S., & Suzuki, M. (2007). Aging gracefully: A retrospective analysis of functional status in Okinawan centenarians. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 15(3), 252-256. Pubmed PMID: 17322136.

Willcox B. J., Willcox D. C., Todoriki H, Yano K, Curb JD, Suzuki M. (2007). Caloric restriction, energy balance and healthy aging in Okinawans and Americans: biomarker differences in septuagenarians. The Okinawan Journal of American Studies 4, 62-74.

Suzuki M, Willcox D. C., Willcox B. J. (2007). The historical context of Okinawan longevity: influence of the United States and Mainland Japan. The Okinawan Journal of American Studies 4, 46-61.

Willcox, D. C., Willcox, B. J., Hsueh, W. C., & Suzuki, M. (2006). Genetic determinants of exceptional human longevity: Insights from the Okinawa Centenarian Study. Age (Dordrecht, Netherlands), 28(4), 313-332. Pubmed PMID: 22253498.

Willcox, B. J. (2006). Age editorial. Age (Dordrecht, Netherlands), 28(4), 309-311. Pubmed PMID: 22253497.

Yanagita, M., Willcox, B. J., Masaki, K. H., Chen, R., He, Q., Rodriguez, B. L., . . . Curb, J. D. (2006). Disability and depression: Investigating a complex relation using physical performance measures. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 14(12), 1060-1068. Pubmed PMID: 17138811.

Willcox, B. J., He, Q., Chen, R., Yano, K., Masaki, K. H., Grove, J. S., . . . Curb, J. D. (2006b). Midlife risk factors and healthy survival in men. JAMA, 296(19), 2343-2350. Pubmed PMID: 17105797.

Willcox, D. C., Willcox, B. J., Todoriki, H., Curb, J. D., & Suzuki, M. (2006). Caloric restriction and human longevity: What can we learn from the Okinawans? Biogerontology, 7(3), 173-177. Pubmed PMID: 16810568.

Curb, J. D., Ceria-Ulep, C. D., Rodriguez, B. L., Grove, J., Guralnik, J., Willcox, B. J., . . . Chen, R. (2006). Performance-based measures of physical function for high-function populations. Journal of the American Geriatrics Society, 54(5), 737-742. Pubmed PMID: 16696737.

Willcox, B. J., Willcox, D. C., He, Q., Curb, J. D., & Suzuki, M. (2006). Siblings of Okinawan centenarians share lifelong mortality advantages. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 61(4), 345-354. Pubmed PMID: 16611700.

2000-2004

Bernstein, A. M., Willcox, B. J., Tamaki, H., Kunishima, N., Suzuki, M., Willcox, D. C., . . . Perls, T. T. (2004). First autopsy study of an okinawan centenarian: Absence of many age-related diseases. The Journals of Gerontology.Series A, Biological Sciences and Medical Sciences, 59(11), 1195-1199. Pubmed PMID: 15602075.

Willcox, B. J., Yano, K., Chen, R., Willcox, D. C., Rodriguez, B. L., Masaki, K. H., . . . Curb, J. D. (2004). How much should we eat? the association between energy intake and mortality in a 36-year follow-up study of Japanese-American men. The Journals of Gerontology.Series A, Biological Sciences and Medical Sciences, 59(8), 789-795. Pubmed PMID: 15345727.

Willcox, B. J., & Scott, J. N. (2004). Growth-associated proteins and regeneration-induced gene expression in the aging neuron. Mechanisms of Ageing and Development, 125(7), 513-516. Pubmed PMID: 15246747.

Willcox, B. J., Abbott, R. D., Yano, K., Rodriguez, B. L., Willcox, D. C., & Curb, J. D. (2004). C-reactive protein, cardiovascular disease and stroke: New roles for an old biomarker. Expert Review of Neurotherapeutics, 4(3), 507-518. Pubmed PMID: 15853546.

Suzuki M, Willcox B. J., Willcox D.C. (2004). Successful aging: Secrets of Okinawan longevity. Geriatrics and Gerontology International, 4(4): S180-181. Available from https://doi.org/10.1111/j.1447-0594.2004.00193.x

Todoriki H, Willcox D. C., Willcox B. J. (2004). The effects of post-war dietary change on longevity and health in Okinawa. The Okinawan Journal of American Studies, 1:55-64. Available from http://ir.lib.u-ryukyu.ac.jp/bitstream/20.500.12000/6775/1/KJ00004245918.pdf

Suzuki M, Tamaki M, Higa K, Willcox D. C. (2003). ADL and its relation to personality in Okinawan-Japanese community dwelling centenarians. Okinawa International University Journal of Social Welfare and Psychology, 1(1):39-49.

Todoriki H, Willcox D. C., Kinjo Y, Takakura M, Sasaki S, Ariizumi M. (2002). The post-war nutrition transition in Okinawa: Changes in body composition and fat intake. Japanese Journal of Health and Human Ecology 68:56-57. [Japanese]

Willcox D. C., Willcox B. J., Suzuki M. (2002). Evidence-based exceptional longevity: The demography of centenarians in Japan. J Cheju Island Studies, 22, 85-86. [Korean]

Suzuki, M. (2001). Cultural climate and social custom for longevity region, Okinawa. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 38(2), 163-165. Pubmed PMID: 11305027.

Suzuki, M., Wilcox, B. J., & Wilcox, D. C. (2001). Implications from and for food cultures for cardiovascular disease: Longevity. Asia Pacific Journal of Clinical Nutrition, 10(2), 165-171. Pubmed PMID: 11710359.

Willcox, B. J., Willcox, D. C., & Suzuki, M. (2001). The Okinawa program: How the world’s longest-lived people achieve everlasting health–and how you can too. Three Rivers Press.

BEFORE 2000

Nozaki, H., Nohara, Y., Ashitomi, I., Zukeran, R., Inafuku, T., Akisaka, M., & Suzuki, M. (1998). Serum globulin levels and activities of daily living in centenarians. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 35(9), 680-685. Pubmed PMID: 9865062.

Akisaka, M., & Suzuki, M. (1998). Okinawa longevity study. molecular genetic analysis of HLA genes in the very old. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 35(4), 294-298. Pubmed PMID: 9643013.

Akisaka, M., Suzuki, M., & Inoko, H. (1997). Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity. Tissue Antigens, 50(5), 489-493. Pubmed PMID: 9389323.

Akisaka, M., Tanaka, Y., & Suzuki, M. (1997). Longitudinal and comprehensive follow-up study of the oldest man in Japan. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 34(4), 312-323. Pubmed PMID: 9212687.

Akisaka, M., Asato, L., Chan, Y. C., Suzuki, M., Uezato, T., & Yamamoto, S. (1996). Energy and nutrient intakes of Okinawan centenarians. Journal of Nutritional Science and Vitaminology, 42(3), 241-248. Pubmed PMID: 8866260.

Akisaka, M., Nohara, Y., & Suzuki, M. (1996). Family history and the frequency of human leukocyte antigen (HLA-DR) in centenarians. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 33(3), 180-185. Pubmed PMID: 8648894.

Nozaki, H., Ashitomi, I., Higa, K., Akisaka, M., & Suzuki, M. (1995). Red blood cell parameters of healthy centenarians. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 32(7), 471-477. Pubmed PMID: 7500549.

Akisaka, M., Ashitomi, I., Adachi, M., Tanaka, Y., & Suzuki, M. (1993). The relationship between aortic pulse wave velocity and atherogenic index in centenarians. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 30(6), 467-473. Pubmed PMID: 8361064.

Willcox, B. J., Poulin, P., Veale, W. L., & Pittman, Q. J. (1992). Vasopressin-induced motor effects: Localization of a sensitive site in the amygdala. Brain Research, 596(1-2), 58-64. Pubmed PMID: 1468003.

Herzog, W., Conway, P. J., & Willcox, B. J. (1991). Effects of different treatment modalities on gait symmetry and clinical measures for sacroiliac joint patients. Journal of Manipulative and Physiological Therapeutics, 14(2), 104-109. Pubmed PMID: 1826920

Willcox, B. J., Poulin, P., Pittman, Q. J., & Veale, W. L. (1991). Arginine vasopressin induced motor disturbances in the medial amygdala: Evidence for the involvement of a V1-type of AVP receptor. Proceedings of the Western Pharmacology Society, 34, 291-295. Pubmed PMID: 1788301.

Takata, H., Suzuki, M., Ishii, T., Sekiguchi, S., & Iri, H. (1987). Influence of major histocompatibility complex region genes on human longevity among Okinawan-Japanese centenarians and nonagenarians. Lancet, 2(8563), 824-826. Pubmed PMID: 2889033.

Suzuki, M., Mori, H., Asato, T., Sakugawa, H., Ishii, T., & Hosoda, Y. (1985). Medical researches upon centenarians in Okinawa (1)–case controlled study of family history as hereditary influence on longevity. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 22(5), 457-467. PubMed PMID: 4079105.

Sanabe, E., I. Ashitomi and M. Suzuki. (1977). “Social and medical survey of centenarians.” Okinawa Journal of Public Health 9, 98-106.